Nobel Laureate Stanley Prusiner is due at swag外流 next week to give a public talk on 鈥淏rain Injuries: Soldiers, Football Players and Alzheimer鈥檚 Patients."
The neurologist, a professor at UC San Francisco, discovered a class of infectious proteins that cause mad cow disease and related neurodegenerative ailments in animals and people.
His talk is scheduled for 5:30 p.m. Friday, Oct. 12, in Freeborn Hall. Admission is free.
Earlier in the day, in a more technical presentation, he is scheduled to address veterinary students on 鈥淭he Molecular Biology of Mammalian Prions.鈥 The lecture is set to begin at noon in 1020 Valley Hall.
The School of Veterinary Medicine is organizing Prusiner's visit, which is sponsored by the Robert Dyar Labrador Memorial Lectureship in Epidemiology.
Dyar, a physician who served for 30 years as chief of the Preventive Medicine and Research divisions in the California Department of Public Health, endowed the lectureship program to recognize swag外流鈥 pioneer achievements in the field of veterinary epidemiology and to extend his gratitude to veterinarians for the medical care provided to his companion Labrador retrievers. Dyar died in 1992 at the age of 83.
Prusiner, director of the Institute for Neurodegenerative Diseases at UCSF, received the 1997 Nobel Prize in Physiology or Medicine for his discovery of the disease-causing proteins that he named prions.
His research demonstrated that prions are formed and become infectious when a normal, benign cellular protein acquires an altered shape 鈥 a theory that he recalls initially unleashed a 鈥渢orrent of criticism鈥 in the scientific community. At that time, most scientists thought that proteins could have only one biologically active form.
Eventually, evidence for prions accumulated and the concept of their infectious abilities gained wide acceptance among scientists. During the past 20 years, abnormalities in protein processing have also been found to be the cause of more common neurodegenerative diseases like Alzheimer鈥檚 and Parkinson鈥檚.
Today, his research focuses on determining the atomic structure of prions, deciphering how they replicate and defining how biological properties are encoded in prion strains. He also is working to develop therapeutic drugs that slow the decline in patients with Alzheimer鈥檚, Parkinson鈥檚 and prion diseases, as well as frontotemporal dementia.
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Dave Jones, Dateline, 530-752-6556, dljones@ucdavis.edu